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Pathways Recommended:	JAK/STAT Signaling Neuronal Signaling

Results for "

Signal transducer and activator of transcription (STAT)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	STAT (10) Akt (1) Apoptosis (7) Bcl-2 Family (2) c-Myc (1) Interleukin Related (1) JAK (4) MMP (1) PROTACs (1) Reference Standards (1) Survivin (1)
By Research Areas:	Cancer (12) Inflammation/Immunology (1)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Antibodies

Targets Recommended: STAT Microphthalmia Associated Transcription Factor (MITF) ERK OLIG2 ATF6 RUNX ASK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128588

STAT3-IN-3 5+ Cited Publications	STAT Apoptosis	Cancer
STAT3-IN-3 is a potent and selective inhibitor of **signal transducer and activator of transcription 3 (STAT3)*, with anti-proliferative activity. STAT3-IN-3 induces apoptosis* in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research .

HY-100602

HJC0152 3 Publications Verification	STAT Apoptosis	Cancer
HJC0152 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.

HY-176949

STAT6-IN-10	STAT	Inflammation/Immunology
STAT6-IN-10 is a STAT6 (signal transducer and activator of transcription 6) inhibitor with an EC₅₀ of 2 nM. STAT6-IN-10 can inhibit the secretion of CCL17 in human peripheral whole blood. STAT6-IN-10 can be used in the research of dermatological and respiratory system diseases .

HY-147187

MNK8	STAT Apoptosis Bcl-2 Family Survivin	Cancer
MNK8 is a potent *STAT3* (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells .

HY-172767

STAT3-D11-PROTAC-VHL	PROTACs STAT Apoptosis	Cancer
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting Signal Transducer and Activator of Transcription 3 (STAT3). STAT3-D11-PROTAC-VHL exhibits anti-tumor activity with IC₅₀ values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. STAT3-D11-PROTAC-VHL binds to the DNA-binding domain of STAT3 and recruits the E3 ligase VHL to form a ternary complex, leading to the ubiquitination of STAT3 and subsequent degradation by the proteasome. STAT3-D11-PROTAC-VHL also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion .

HY-E70873

Tyk2(JH1/JH2) Recombinant Human Active Protein Kinase	JAK	Cancer
TYK2 is a member of the JAK family of non-receptor tyrosine kinases that act together with signal transducer and activator of transcription (STAT) factors in mediating intracellular signal transduction. JAKs are characterized by dual kinase domain: a tyrosine kinase domain (JH1) that is preceded by a pseudokinase domain (JH2). Tyk2(JH1/JH2) Recombinant Human Active Protein Kinase is a recombinant Tyk2(JH1/JH2) protein that can be used to study Tyk2(JH1/JH2)-related functions .

HY-175771

STAT3-IN-46	STAT c-Myc Bcl-2 Family Interleukin Related JAK	Cancer
STAT3-IN-46 is a selective and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) (K_D = 323.3 nM). STAT3-IN-46 directly binds to the SH2 domain of the STAT3 and inhibits IL-6/JAK/STAT3 signaling pathway (IC₅₀ = 0.87 μM) and downregulates c-Myc and Bcl-2 levels. STAT3-IN-46 can be used for the research of cancer, such as triple-negative breast cancer .

HY-116278

HJC0149	STAT	Cancer
HJC0149 is a potent and orally active inhibitor of signal transducer and activator of **transcription 3 (STAT3)** .

HY-161351

STAT3/AKT-IN-1	Akt STAT Apoptosis	Cancer
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .

HY-E70872

TYK2(JH1) Recombinant Human Active Protein Kinase	JAK	Cancer
TYK2 is a member of the JAK family of non-receptor tyrosine kinases that act together with signal transducer and activator of transcription (STAT) factors in mediating intracellular signal transduction. JAKs are characterized by dual kinase domain: a tyrosine kinase domain (JH1) that is preceded by a pseudokinase domain (JH2). TYK2(JH1) Recombinant Human Active Protein Kinase is a recombinant TYK2(JH1) protein that can be used to study TYK2(JH1)-related functions .

HY-E70874

TYK2(JH2) Recombinant Human Active Protein Kinase	JAK	Cancer
TYK2 is a member of the JAK family of non-receptor tyrosine kinases that act together with signal transducer and activator of transcription (STAT) factors in mediating intracellular signal transduction. JAKs are characterized by dual kinase domain: a tyrosine kinase domain (JH1) that is preceded by a pseudokinase domain (JH2). TYK2(JH2) Recombinant Human Active Protein Kinase is a recombinant TYK2(JH2) protein that can be used to study TYK2(JH2)-related functions .

HY-100602R

HJC0152 (Standard)	STAT Reference Standards Apoptosis	Cancer
HJC0152 (Standard) is the analytical standard of HJC0152 (HY-100602). This product is intended for research and analytical applications. HJC0152 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.

HY-177990

STAT3-IN-52	STAT MMP Apoptosis	Cancer
STAT3-IN-52 (Compound 9) is a selective and orally active signal transducer and activator of transcription 3 (STAT3) inhibitor. STAT3-IN-52 binds to the pY705 site of STAT3 (K_i = 440 nM), blocking the phosphorylation and dimerization of STAT3. STAT3-IN-52 shows strong cytotoxicity against various cancer cells, such as breast cancer MDA-MB-231 (IC₅₀ = 0.7 μM), medulloblastoma UW426, pancreatic cancer BKPC3 cells. STAT3-IN-52 can induce cell apoptosis, inhibit the STAT3 nuclear transport and DNA binding activity and downregulate the expression of the STAT3 target gene MMP9. STAT3-IN-52 can be used for research related to STAT3 abnormal activation in cancer .

Cat. No.	Product Name

HY-L008

JAK/STAT Compound Library	704 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 704 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

704 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 704 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Species:	Human (12)
Tag:	His (11) Tag Free (1) Strep (1) GST (2)
Source:	Sf9 insect cells (4) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701098

	STAT3 Protein, Human (Full Length, His) STAT3; Signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and activator of transcription 3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (Full Length, His) is the recombinant human-derived STAT3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704899

	STAT3 Protein, Human (562a.a, His) STAT3; Signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and activator of transcription 3; APRF	Human	E. coli

HY-P71337

	STAT6 Protein, Human (His) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P76664

	STAT4 Protein, Human (sf9, His) Signal transducer and activator of transcription 4; STAT4	Human	Sf9 insect cells
	The STAT4 protein is mainly expressed in hematopoietic cells and is critical for cell growth, differentiation and immune responses. It plays a key role in T helper 1 cell differentiation, interferon gamma production, and various neutrophil activities. STAT4 Protein, Human (sf9, His) is the recombinant human-derived STAT4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P71336

	STAT5B Protein, Human (His) Signal transducer and activator of transcription 5B; STAT5B	Human	E. coli
	The STAT5B protein plays dual roles in signal transduction and transcriptional activation in response to KITLG/SCF and growth factors. STAT5B Protein, Human (His) is the recombinant human-derived STAT5B protein, expressed by E. coli , with C-6*His labeled tag.

HY-P702835A

	STAT6 Protein, Human (536a.a, His) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

HY-P70574

	STAT3 Protein, Human (His) Signal transducer and activator of transcription 3; Acute-Phase Response Factor; STAT3; APRF	Human	E. coli
	STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (His) is the recombinant human-derived STAT3 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P702835

	STAT6 Protein, Human (Phosphorylated, 536a.a, His) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	E. coli
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (Phosphorylated, 536a.a, His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with N-His labeled tag.

HY-P703579

	STAT6 Protein, Human (sf9, His, StrepⅡ) Signal transducer and activator of transcription 6; IL-4 Stat; STAT6	Human	Sf9 insect cells
	STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (sf9, His, Strep) is the recombinant human-derived STAT6 protein, expressed by Sf9 insect cells , with C-His; C-Strep labeled tag.

HY-P73628

	STAT1 Protein, Human (sf9, His-GST) 2 Publications Verification Signal transducer and activator of transcription 1-Alpha/Beta; STAT1	Human	Sf9 insect cells
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human (sf9, His-GST) is the recombinant human-derived STAT1 protein, expressed by Sf9 insect cells , with N-10*His, N-GST labeled tag.

HY-P73628Y

	STAT1 Protein, Human (sf9, His-GST, solution) Signal transducer and activator of transcription 1-Alpha/Beta; STAT1	Human	Sf9 insect cells
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human (sf9, His-GST, solution) is the recombinant human-derived STAT1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P71335

	STAT1 Protein, Human 2 Publications Verification Signal transducer and activator of transcription 1-Alpha/Beta; transcription Factor ISGF-3 Components p91/p84; STAT1	Human	E. coli
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human is the recombinant human-derived STAT1 protein, expressed by E. coli , with tag free.

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Host:	Mouse (3) Rabbit (17)
Reactivity:	Human (20) Rat (16) Mouse (17) Monkey (2) Dog (1)
Application:	IHC-P (19) ICC/IF (13) IF-Tissue (1) IP (11) IHC-F (2) WB (20) FC (1) ELISA (10)
Isotype:	IgG (15) IgG1 (2) IgG2a (1) IgG/Kappa (2)
Conjugation:	Non-conjugated (20)
Clonality:	Polyclonal (3) Monoclonal (16) Recombinant (6)
Modification:	Phosphorylated (6) Unmodified (13)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86331

	STAT5a+b Antibody (YA6023) STAT5A; STAT5; Signal transducer and activator of transcription 5A; STAT5B; Signal transducer and activator of transcription 5B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STAT5a+b Antibody (YA6023) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT5a+b.

HY-P80903

	STAT4 Antibody (YA055) STAT4; Signal transducer and activator of transcription 4	WB, IHC-P, IP	Human
	STAT4 Antibody (YA055) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT4.

HY-P86203

	Phospho-STAT5a+b(Tyr694) Antibody (YA5895) STAT5A; STAT5; Signal transducer and activator of transcription 5A; STAT5B; Signal transducer and activator of transcription 5B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-STAT5a+b(Tyr694) Antibody (YA5895) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT5a+b(Tyr694).

HY-P85377

	STAT6 Antibody (YA5069) STAT6; Signal transducer and activator of transcription 6; IL-4 Stat	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	STAT6 Antibody (YA5069) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to STAT6.

HY-P86241

	STAT6 Antibody (YA5933) STAT6; Signal transducer and activator of transcription 6; IL-4 Stat	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STAT6 Antibody (YA5933) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT6.

HY-P86182

	STAT2 Antibody (YA5874) STAT2; Signal transducer and activator of transcription 2; p113	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	STAT2 Antibody (YA5874) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT2.

HY-P80903A

	STAT4 Antibody (YA055)(PBS only) STAT4; Signal transducer and activator of transcription 4	WB, IHC-P, ICC/IF, IP, FC	Human
	STAT4 Antibody (YA055) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT4.

HY-P86188

	STAT5B Antibody (YA5880) Signal transducer and activator of transcription 5B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STAT5B Antibody (YA5880) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT5B.

HY-P86240

	STAT5a Antibody (YA5932) STAT5A; STAT5; Signal transducer and activator of transcription 5A	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STAT5a Antibody (YA5932) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT5a.

HY-P80902

	STAT3 Antibody (YA666) 1 Publications Verification STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P	Human, Rat, Mouse
	STAT3 Antibody (YA666) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to STAT3.

HY-P86382

	STAT3 Antibody (YA6074) STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STAT3 Antibody (YA6074) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT3.

HY-P81768

	Phospho-STAT5(Tyr694) Antibody (YA1513) STAT5A; STAT5; Signal transducer and activator of transcription 5A	WB, IHC-P	Human, Mouse
	Phospho-STAT5(Tyr694) Antibody (YA1513) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT5(Tyr694).

HY-P80857

	Phospho-STAT3 (Tyr705) Antibody 1 Publications Verification STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-STAT3 (Tyr705) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-STAT3 (Tyr705).

HY-P80479

	Phospho-STAT5a (Tyr694) Antibody (YA145) STAT5A; STAT5; Signal transducer and activator of transcription 5A	WB, IHC-P, ICC/IF	Human, Rat, Mouse
	Phospho-STAT5a (Tyr694) Antibody (YA145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT5a (Tyr694).

HY-P80902A

	STAT3 Antibody (YA666)(PBS only) STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor	WB, IHC-P	Human, Mouse, Rat
	STAT3 Antibody (YA666)(PBS only) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to STAT3.

HY-P80856

	Phospho-STAT1 (Tyr701) Antibody 3 Publications Verification STAT1; Signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84	ICC/IF, WB, IHC-F, IHC-P, IP, ELISA	Human, Mouse, Rat, Monkey
	Phospho-STAT1 (Tyr701) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-STAT1 (Tyr701).

HY-P85794

	STAT1 Antibody (YA5486) Signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84;	WB, ICC/IF, ELISA	Human, Dog
	STAT1 Antibody (YA5486) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to STAT1.

HY-P80855

	Phospho-STAT1 (Ser727) Antibody (YA149) 2 Publications Verification STAT1; Signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84	WB, IHC-P	Human, Mouse, Rat
	Phospho-STAT1 (Ser727) Antibody (YA149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT1 (Ser727).

HY-P80856A

	Phospho-STAT1 (Tyr701) Antibody（PBS only） STAT1; Signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat, Monkey
	Phospho-STAT1 (Tyr701) Antibody（PBS only） is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-STAT1 (Tyr701).

HY-P80855A

	Phospho-STAT1 (Ser727) Antibody (YA149)(PBS only) STAT1; Signal transducer and activator of transcription 1-alpha/beta; transcription factor ISGF-3 components p91/p84	WB, IHC-P	Human, Mouse, Rat
	Phospho-STAT1 (Ser727) Antibody (YA149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT1 (Ser727).

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